Foretinib-Based PROTAC 7 ( —— )

Catalog No. M13576 CAS No. 2230821-68-6

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Product Name

Foretinib-Based PROTAC 7
Note

Research use only, not for human use.
Brief Description

Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
Description

Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.
Synonyms

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Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

2230821-68-6
Formula Weight

1106.25
Molecular Formula

C58H65F2N7O11S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.

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